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Gestione del dolore acuto



1. Abelson AL, et al. Use of wound soaker catheters for the administration of local anesthetic for post-operative analgesia: 56 cases. Vet Anaesth Analg. 2009 Nov;36(6):597-602. doi: 10.1111/j.1467-2995.2009.00487.x. PMID: 19845933.

2. Belli M, de Oliveira AR, de Lima MT, Trindade PHE, Steagall PV, Luna SPL. Clinical validation of the short and long UNESP-Botucatu scales for feline pain assessment. PeerJ. 2021 Apr 12;9:e11225. doi: 10.7717/peerj.11225. PMID: 33954046; PMCID: PMC8048399.

3. Berry SH. Analgesia in the perioperative period. Vet Clin North Am Small Anim Pract 2015;45:1013-27.

4. Burgess JW, Villablanca JR. Ontogenesis of morphine-induced behavior in the cat. Brain Res 2007;1134:53-61.

5. Campagnol D, Teixeira-Neto FJ, Monteiro ER, et al. Effect of intraperitoneal or incisional bupivacaine on pain and the analgesic requirement after ovariohysterectomy in dogs. Vet Anaesth Analg 2012;39:426-30.

6. Carpenter RE, Wilson DV, Evans AT. Evaluation of intraperitoneal and incisional lidocaine or bupivacaine for analgesia following ovariohysterectomy in the dog. Vet Anaesth Analg 2004;31:46-52.

7. Cozzi EM, Spensley MS. Multicenter randomized prospective clinical evaluation of meloxicam administered via transmucosal oral spray in client-owned dogs. J Vet Pharmacol Ther 2013;36:609-16.

8. Culp WT, Mayhew PD, Brown DC. The effect of laparoscopic versus open ovariectomy on postsurgical activity in small dogs. Vet Surg 2009; 38:811-7.

9. Da Silva Santos R, Galdino G. Endogenous systems involved in exercise induced analgesia. J Physiol Pharmacol 2018;69:3-13.

10. Dahl JB, Kehlet H. Preventive analgesia. Curr Opin Anaesthesiol 2011; 24:331-8.

11. Davila D, Keeshen TP, Evans RB, et al. Comparison of the analgesic efficacy of perioperative firocoxib and tramadol administration in dogs undergoing tibial plateau leveling osteotomy. J Am Vet Med Assoc 2013;243:225-31.

12. Di Bella C, Skouropoulou D, Stabile M, et al. Respiratory and hemodynamic effects of 2 protocols of low-dose infusion of dexmedetomidine in dogs under isoflurane anesthesia. Can J Vet Res 2020;84:96-107.

13. Dyson DH. Perioperative pain management in veterinary patients. Vet Clin North Am Small Anim Pract 2008;38:1309-27, VII.

14.Enomoto M, Lascelles BD, Gerard MP. Defining local nerve blocks for feline distal pelvic limb surgery: a cadaveric study. J Feline Med Surg 2017:19:1215-1223.

15. Enomoto M, Lascelles BD, Gerard MP. Defining the local nerve blocks for feline distal thoracic limb surgery: a cadaveric study. J Feline Med Surg 2016;18:838-45.

16. Epstein ME, Rodan I, Griffenhagen G, et al. 2015 AAHA/AAFP painmanagement guidelines for dogs and cats. J Feline Med Surg 2015;17:251-72.

17. Evangelista MC, Silva RA, Cardozo LB, et al. Comparison of preoperative tramadol and pethidine on postoperative pain in cats undergoing ovariohysterectomy. BMC Vet Res 2014;10:252.

18. Evangelista MC, Watanabe R, Leung VSY, et al. Facial expressions of pain in cats: the development and validation of a Feline Grimace Scale. Sci Rep 2019;9:19128.

19. Evangelista, M.C., Steagall, P.V. Agreement and reliability of the Feline Grimace Scale among cat owners, veterinarians, veterinary students and nurses. Sci Rep 11, 5262 (2021).

20. Friton G, Thompson C, Karadzovska D, et al. Efficacy and safety of injectable robenacoxib for the treatment of pain associated with soft tissue surgery in dogs. J Vet InternMed 2017;31:832-41.

21. Friton G, Thompson CM, Karadzovska D, et al. Efficacy and safety of oral robenacoxib (tablet) for the treatment of pain associated with soft tissue surgery in client-owned dogs. BMC Vet Res 2017;13:197.

22. Gordon-Evans WJ, Suh HY, Guedes AG. Controlled, non-inferiority trial of bupivacaine liposome injectable suspension. J Feline Med Surg 2020;22:916-21.

23. Grubb T, Lobprise H. Local and regional anaesthesia in dogs and cats: descriptions of specific local and regional techniques (Part 2). Vet Med Sci 2020;6:218-34.

24. Grubb T, Lobprise H. Local and regional anaesthesia in dogs and cats: overview of concepts and drugs (Part 1). Vet Med Sci 2020;6:209-17.

25. Hardie EM, Lascelles BD, Meuten T, et al. Evaluation of intermittent infusion of bupivacaine into surgical wounds of dogs postoperatively. Vet J 2011;190:287-289.

26. Hartrick CT, Pestano C, Carlson N, et al. Capsaicin instillation for postoperative pain following total knee arthroplasty: a preliminary report of a randomized, double-blind, parallel-group, placebocontrolled, multicentre trial. Clin Drug Investig 2011;31:877-82.

27. Heit MC, Stallons LJ, Seewald W, et al. Safety evaluation of the interchangeable use of robenacoxib in commercially-available tablets and solution for injection in cats. BMC Vet Res 2020;16:355.

28. Hussain N, Grzywacz VP, Ferreri CA, et al. Investigating the efficacy of dexmedetomidine as an adjuvant to local anesthesia in brachial plexus block: a systematic review and meta-analysis of 18 randomized controlled trials. Reg Anesth Pain Med 2017;42:184-96.

29. Kalchofner Guerrero KS, Campagna I, Bruhl-Day R, et al. Intraperitoneal bupivacaine with or without incisional bupivacaine for postoperative analgesia in dogs undergoing ovariohysterectomy. Vet Anaesth Analg 2016;43:571-8.

30. Kazmir-Lysak K, et al. Use of wound infusion catheters for postoperative local anaesthetic administration in cats. J Feline Med Surg. 2023 Sep;25(9):1098612X231193534. doi: 10.1177/1098612X231193534. PMID: 37713178.

31. Kim YK, Lee SS, Suh EH, et al. Sprayed intraperitoneal bupivacaine reduces early postoperative pain behavior and biochemical stress response after laparoscopic ovariohysterectomy in dogs. Vet J 2012;191:188-92.

32. Kukanich B, Bidgood T, Knesl O. Clinical pharmacology of nonsteroidal anti-inflammatory drugs in dogs. Vet Anaesth Analg 2012;39:69-90.

33. Lambertini C, Kluge K, Lanza-Perea M, et al. Comparison of intraperitoneal ropivacaine and bupivacaine for postoperative analgesia in dogs undergoing ovariohysterectomy. Vet Anaesth Analg 2018;45:865-70.

34. Lascelles BD, Cripps PJ, Jones A, et al. Efficacy and kinetics of carprofen, administered preoperatively or postoperatively, for the prevention of pain in dogs undergoing ovariohysterectomy. Vet Surg 1998;27:568 82.

35. Lascelles BD, Cripps PJ, Jones A, et al. Post-operative central hypersensitivity and pain: the pre-emptive value of pethidine for ovariohysterectomy. Pain 1997;73:461-71.

36. Lascelles BD, McFarland JM, Swann H. Guidelines for safe and effective use of NSAIDs in dogs. Vet Ther 2005;6:237-51.

37. Lascelles BD, Rausch-Derra LC, Wofford JA, et al. Pilot, randomized, placebo-controlled clinical field study to evaluate the effectiveness of bupivacaine liposome injectable suspension for the provision of postsurgical analgesia in dogs undergoing stifle surgery. BMC Vet Res 2016; 12:168.

38. Lemke KA, Creighton CM. Analgesia for anesthetized patients. Top Companion Anim Med 2010;25:70-82.

39. Lemke KA. Understanding the pathophysiology of perioperative pain. Can Vet J 2004;45:405-13.

40. Margaret E. Gruen et al. AAHA Pain Management Guidelines for Dogs and Cats, 2022

41. Marquez M, Boscan P, Weir H, et al. Comparison of NK-1 receptor antagonist (maropitant) to morphine as a pre-anaesthetic agent for canine ovariohysterectomy. PLoS One 2015;10:e0140734.

42. Meunier NV, Panti A, Mazeri S, et al. Randomised trial of perioperative tramadol for canine sterilisation pain management. Vet Rec 2019;185: 406.

43. Norling LV, Serhan CN. Profiling in resolving inflammatory exudates identifies novel anti-inflammatory and pro-resolving mediators and signals for termination. J Intern Med 2010;268:15-24.

44. Pascal M, Allison A, Kaartinen J. Opioid-sparing effect of a medetomidine constant rate infusion during thoraco-lumbar hemilaminectomy in dogs administered a ketamine infusion. Vet Anaesth Analg. 2020 Jan;47(1):61-69. doi: 10.1016/j.vaa.2019.06.012. Epub 2019 Oct 17. PMID: 31791743.

45. Paulo V Steagall et al. ISFM Consensus Guidelines on the Management of Acute Pain in Cats, 2022

46. Posner LP, Pavuk AA, Rokshar JL, et al. Effects of opioids and anesthetic drugs on body temperature in cats. Vet Anaesth Analg 2010;37: 35-43.

47. Raja SN, et al.The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. Pain. 2020 Sep 1;161(9):1976-1982. doi: 10.1097/j.pain.0000000000001939. PMID: 32694387; PMCID: PMC7680716.

48. Slingsby L, Waterman-Pearson A. Analgesic effects in dogs of carprofen and pethidine together compared with the effects of either drug alone. Vet Rec 2001;148:441-4.

49. Sneddon LU. Comparative Physiology of Nociception and Pain. Physiology (Bethesda). 2018 Jan 1;33(1):63-73. doi: 10.1152/physiol.00022.2017. PMID: 29212893.

50. Snyder LB, Snyder CJ, Hetzel S. Effects of buprenorphine added to bupivacaine infraorbital nerve blocks on isoflurane minimum alveolar concentration using a model for acute dental/oral surgical pain in dogs. J Vet Dent 2016;33:90-6.

51. Steagall PV, Monteiro BP. Acute pain in cats: Recent advances in clinical assessment. J Feline Med Surg. 2019 Jan;21(1):25-34. doi: 10.1177/1098612X18808103. Epub 2018 Oct 15. PMID: 30320529.

52. Steagall PV, Ruel HLM, Yasuda T, et al. Pharmacokinetics and analgesic effects of intravenous, intramuscular or subcutaneous buprenorphine in dogs undergoing ovariohysterectomy: a randomized, prospective, masked, clinical trial. BMC Vet Res 2020;16:154.

53. Stoetzer C, Martell C, de la Roche J, et al. Inhibition of voltage-gated Na1 channels by bupivacaine is enhanced by the adjuvants buprenorphine, ketamine, and clonidine. Reg Anesth Pain Med 2017;42:462-8.

54. Tan M, Law LS, Gan TJ. Optimizing pain management to facilitate Enhanced Recovery After Surgery pathways. Can J Anaesth 2015;62: 203-18.

55. Teixeira RC, Monteiro ER, Campagnol D, et al. Effects of tramadol alone, in combination with meloxicam or dipyrone, on postoperative pain and the analgesic requirement in dogs undergoing unilateral mastectomy with or without ovariohysterectomy. Vet Anaesth Analg 2013; 40:641-9.

Pharmacokinetics and efficacy of intravenous and extradural tramadol in dogs. Vet J 2010;183:310-5.

57. Wagner AE, Walton JA, Hellyer PW, Gaynor JS, Mama KR. Use of low doses of ketamine administered by constant rate infusion as an adjunct for postoperative analgesia in dogs. J Am Vet Med Assoc. 2002 Jul 1;221(1):72-5. doi: 10.2460/javma.2002.221.72. PMID: 12420827.

58. Watanabe R, Marcoux J, Evangelista MC, et al. The analgesic effects of buprenorphine (Vetergesic or Simbadol) in cats undergoing dental.

59. Watanabe R, Monteiro BP, Evangelista MC, et al. The analgesic effects of buprenorphine (Vetergesic or Simbadol) in combination with carprofen in dogs undergoing ovariohysterectomy: a randomized, blinded, clinical trial. BMC Vet Res 2018;14:304.

60. Xu J, Brennan TJ. Guarding pain and spontaneous activity of nociceptors after skin versus skin plus deep tissue incision. Anesthesiology 2010;112:153-64.



Per saperne di più

- Della Rocca, Bufalari. Terapia del dolore negli animali da compagnia, 2016, Poletto editore.

- Gaynor, Muir III. Handbook of veterinary pain management, third edition, 2015, Elsevier.

- Henke, Erhardt. Terapia del dolore degli animali da compagnia, edizione italiana, 2006, Masson editore.

- Self. BSAVA guide to pain management in small animal practice, 2019, BSAVA.




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Patologia comparata del tumore alla prostata del cane e dell'uomo

Sebbene relativamente raro nei cani, il cancro alla prostata (PCa) è il tumore non cutaneo più comune negli uomini. Le ghiandole prostatiche umane e canine condividono molte caratteristiche funzionali, anatomiche e fisiologiche. A causa di queste somiglianze, il PCa canino è stato proposto come modello per il PCa negli uomini.

Formazione a distanza abbinata a SUMMA